This project aims to understand how high-grade serous ovarian cancer (HGSOC) metastasizes and develops resistance to chemotherapy, focusing on late-stage diagnosis. A 3D cancer atlas will be created using molecular and cellular profiling to map tumor progression in patients. The data will help identify key molecular changes responsible for resistance and could lead to more effective treatments and improved survival rates. The multi-disciplinary team will integrate various technologies to produce a comprehensive spatial map of ovarian cancer.